Cooperative chemoenzymatic synthesis of N-heterocycles via synergizing bio- with organocatalysis.

ABSTRACT: Inspired by Nature's ingenuity, considerable progress has been made in recent years to develop chemoenzymatic processes by the integration of environmentally friendly feature of biocatalysis with versatile reactivity of chemocatalysis. However, the current types of chemoenzymatic processes are relatively few and mostly rely on metal catalysts. Here, we report a previously unexplored cooperative chemoenzymatic system for the synthesis of N-heterocycles. Starting from alcohols and amines, benzimidazole, pyrazine, quinazoline, indole, and quinoline can be obtained in excellent yields in water with O₂ as the terminal oxidant. Synthetic bridged flavin analog is served as a bifunctional organocatalyst for the regeneration of cofactor nicotinamide adenine dinucleotide in the bioprocess

SUBMITTER: Tan Z 

PROVIDER: S-EPMC9451157 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature