Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients.

ABSTRACT: COVID-19 is characterized by a wide spectrum of disease severity, whose indicators and underlying mechanisms need to be identified. The role of extracellular vesicles (EVs) in COVID-19 and their biomarker potential, however, remains largely unknown. Aiming to identify specific EV signatures of patients with mild compared to severe COVID-19, we characterized the EV composition of 20 mild and 26 severe COVID-19 patients along with 16 sex and age-matched healthy donors with a panel of eight different antibodies by imaging flow cytometry (IFCM). We correlated the obtained data with 37 clinical, prerecorded biochemical and immunological parameters. Severe patients' sera contained increased amounts of CD13⁺ and CD82⁺ EVs, which positively correlated with IL-6-producing and

SUBMITTER: Tertel T 

PROVIDER: S-EPMC9451525 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature