Atrial fibrillation bleeding risk and prediction while treated with direct oral anticoagulants in warfarin-naive or warfarin-experienced patients.

ABSTRACT:

Background

In patients with atrial fibrillation (AF) treated with direct oral anticoagulants (DOAC), bleeding risk scores provide only modest discrimination for major or intracranial bleeding. However, warfarin experience may impact HAS-BLED  (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly) score performance in patients evaluated for DOACs, as HAS-BLED was derived and validated in warfarin cohorts.

Methods

We performed a retrospective cohort study of patients prescribed DOAC for AF in the Veterans Health Administration between 2010 and 2017. We determined modified HAS-BLED score discrimination and calibration for bleeding, for patients treated wit

SUBMITTER: Perino AC 

PROVIDER: S-EPMC9451662 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature