Prevalence and risk factors of nonalcoholic steatohepatitis with significant fibrosis in people with HIV.

ABSTRACT:

Objective

Metabolic risk factors and nonalcoholic fatty liver disease (NAFLD) in people with HIV (PWH) have been increasing. Patients exhibiting the inflammatory subtype nonalcoholic steatohepatitis (NASH) are at increased risk of liver-related complications. Therefore, the aim was to investigate the prevalence of NASH with significant fibrosis in PWH using noninvasive tests (NITs).

Design

In this prospectively enrolling cohort study, 282 PWH were explored for hepatic steatosis, fibrosis and steatohepatitis using vibration-controlled transient elastography (VCTE) and the Fibroscan-AST (FAST) score.

Methods

On the basis of controlled attenuation parameter (CAP; dB/m) and liver stiffness measurement (LSM; kPa), patients were categorized according to the presence of stea

SUBMITTER: Michel M 

PROVIDER: S-EPMC9451864 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature