Immunologic phenotype of patients with long-COVID syndrome of 1-year duration.

ABSTRACT:

Background

The pathophysiology of long-COVID remains unknown, and information is particularly limited for symptoms of very long duration. We aimed to assess the serological, T-cell immune responses and ANA titers of patients with long-COVID-19 syndrome of 1-year duration.

Methods

Prospective, longitudinal study of hospitalized COVID-19 patients followed-up for 12 months. Sequential blood samples and COVID-19 symptom questionnaires (CSQ) were obtained, and humoral and cellular immune responses, antinuclear antibodies (ANA) and inflammation biomarkers were analyzed.

Results

Of 154 patients discharged from hospital, 72 non-vaccinated with available CSQ in all visits were included. Of them, 14 (19.4%) reported persistent symptoms both at 6-months and 12-months, mainly ast

SUBMITTER: Garcia-Abellan J 

PROVIDER: S-EPMC9451924 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature