Molecular approach of auditory neuropathy.

ABSTRACT:

Introduction

Mutations in the otoferlin gene are responsible for auditory neuropathy.

Objective

To investigate the prevalence of mutations in the mutations in the otoferlin gene in patients with and without auditory neuropathy.

Methods

This original cross-sectional case study evaluated 16 index cases with auditory neuropathy, 13 patients with sensorineural hearing loss, and 20 normal-hearing subjects. DNA was extracted from peripheral blood leukocytes, and the mutations in the otoferlin gene sites were amplified by polymerase chain reaction/restriction fragment length polymorphism.

Results

The 16 index cases included nine (56%) females and seven (44%) males. The 13 deaf patients comprised seven (54%) males and six (46%) females. Among the 20 normal-hearing subj

SUBMITTER: Silva MA 

PROVIDER: S-EPMC9452229 | biostudies-literature | 2015 May-Jun

REPOSITORIES: biostudies-literature