Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.

ABSTRACT: Brown adipose tissue (BAT) dissipates energy^1,2 and promotes cardiometabolic health³. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis. Here, untargeted metabolomics demonstrated that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched. This apoptotic secretome enhances expression of the thermogenic programme in healthy adipocytes. This effect is mediated by the purine inosine that stimulates energy expenditure in brown adipocytes by the cyclic adenosine monophosphate-protein kinase A signalling pathway. Treatment of mice with inosine increased BAT-dependent energy expenditure and induced 'browning' of white adipose tis

SUBMITTER: Niemann B 

PROVIDER: S-EPMC9452294 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature