Fos ensembles encode and shape stable spatial maps in the hippocampus.

ABSTRACT: In the hippocampus, spatial maps are formed by place cells while contextual memories are thought to be encoded as engrams^1-6. Engrams are typically identified by expression of the immediate early gene Fos, but little is known about the neural activity patterns that drive, and are shaped by, Fos expression in behaving animals^7-10. Thus, it is unclear whether Fos-expressing hippocampal neurons also encode spatial maps and whether Fos expression correlates with and affects specific features of the place code¹¹. Here we measured the activity of CA1 neurons with calcium imaging while monitoring Fos induction in mice performing a hippocampus-dependent spatial learning task in virtual reality. We find that neurons with high Fos induction form ensembles of cells wi

SUBMITTER: Pettit NL 

PROVIDER: S-EPMC9452297 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature