Identification of molecular mechanism and key biomarkers in membranous nephropathy by bioinformatics analysis.

ABSTRACT:

Objectives

Membranous nephropathy (MN) is an autoimmune nephropathy. The incidence of MN is increasing gradually in recent years. Previous studies focused on antibody production, complement activation and podocyte injury in MN. However, the etiology and underlying mechanism of MN remain to be further studied.

Methods

GSE104948 and GSE108109 of glomerular expression profile were downloaded from Gene Expression Omnibus (GEO) database, GSE47184, GSE99325, GSE104954, GSE108112, GSE133288 of renal tubule expression profile, and GSE73953 of peripheral blood mononuclear cells (PBMCs) expression profile. After data integration by Networkanalyst, differentially expressed genes (DEGs) between MN and healthy samples were obtained. DEGs were enriched in gene ontology (GO) and Kyoto ency

SUBMITTER: Dong Z 

PROVIDER: S-EPMC9452341 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature