The antifibrotic effects of the novel compound gorse isoflavone alkaloid on chemical liver injury in rats.

ABSTRACT:

Objective

Liver fibrosis is a frequently occurring liver injury which lacks of effective treatment clinically. Here, we investigated the protective effects of a novel compound Gorse isoflavone alkaloid (GIA) against liver fibrosis.

Methods

Totally forty rats were randomly divided into four groups. Then we established a model of liver fibrosis induced by the intragastric administration of carbon tetrachloride (CCl₄). This treated group was followed by the intragastric administration of GIA and colchicine. Then the liver index and spleen index, and liver function indexes were detected by kit. Western blotting assay was performed to estimate the expression of Transforming Growth Factor-β1 (TGF-β1) and related proteins. Tissue fibrosis was observed by Masson staining.

SUBMITTER: Ai YW 

PROVIDER: S-EPMC9452342 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature