Mild Traumatic Brain Injury and Subsequent Acute Pulmonary Inflammatory Response.

ABSTRACT:

Objective

The influence of moderate-to-severe traumatic brain injury (TBI) on acute pulmonary injury is well established, but the association between acute pulmonary injury and mild TBI has not been well studied. Here, we evaluated the histological changes and fluctuations in inflammatory markers in the lungs to determine whether an acute pulmonary inflammatory response occurred after mild TBI.

Methods

Mouse models of mild TBI (n=24) were induced via open-head injuries using a stereotaxic impactor. The brain and lungs were examined 6, 24, and 72 hours after injury and compared to sham-operated controls (n=24). Fluoro-Jade B staining and Astra blue and hematoxylin staining were performed to assess cerebral neuronal degeneration and pulmonary histological architecture. Quantit

SUBMITTER: Lim SH 

PROVIDER: S-EPMC9452391 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature