Identification of Hub Genes in the Pathogenesis of Ischemic Stroke Based on Bioinformatics Analysis.

ABSTRACT:

Objective

The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis.

Methods

Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, an

SUBMITTER: Yang X 

PROVIDER: S-EPMC9452394 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature