[Vagus nerve stimulation for difficult to treat depression].

ABSTRACT:

Introduction

For the past 20 years vagus nerve stimulation (VNS) has been an approved invasive treatment option for treatment-resistant depression (TRD) across Europe. In contrast to more common treatments, such as ECT, knowledge about VNS is low both in the general population and among professionals.

Methods

In this narrative review, we provide a clinically and scientifically sound overview of VNS. Hypotheses on the mechanism of action as well as the current evidence base on efficacy are presented. Perioperative management, adverse event profile and follow-up including dose titration are described. A comparison of international guideline recommendations on VNS is also provided. Furthermore, we formulate criteria that are helpful in the selection of appropriate patients.

SUBMITTER: Reif-Leonhard C 

PROVIDER: S-EPMC9452433 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature