Serum Thyrotropin Elevation and Coronary Artery Calcification in Hemodialysis Patients.

ABSTRACT:

Introduction

Hypothyroidism is highly prevalent in end-stage kidney disease patients, and emerging data show that lower circulating thyroid hormone levels lead to downregulation of vascular calcification inhibitors and coronary artery calcification (CAC) in this population. To date, no studies have examined the association of serum thyrotropin (TSH), the most sensitive and specific single biochemical metric of thyroid function, with CAC risk in hemodialysis patients.

Methods

In secondary analyses of patients from the Anti-Inflammatory and Anti-Oxidative Nutrition in Hypoalbuminemic Dialysis Patients trial, we examined serum TSH levels and CAC risk assessed by cardiac computed tomography scans collected within a 90-day period. We evaluated the relationship between serum TSH w

SUBMITTER: Rhee CM 

PROVIDER: S-EPMC9452456 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature