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Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO₂.

ABSTRACT: Simple access to aryl sulfinates from aryl iodides and bromides is reported using an inexpensive Ni-electrocatalytic protocol. The reaction exhibits a broad scope, uses stock solution of simple SO₂ as sulfur source, and can be scaled up in batch and recycle flow settings. The limitations of this reaction are clearly shown and put into context by benchmarking with state-of-the-art Pd-based methods.

SUBMITTER: Lou TS

PROVIDER: S-EPMC9452475 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2.

Lou Terry Shing-Bong TS Kawamata Yu Y Ewing Tamara T Correa-Otero Guillermo A GA Collins Michael R MR Baran Phil S PS

Angewandte Chemie (International ed. in English) 20220803 37

Simple access to aryl sulfinates from aryl iodides and bromides is reported using an inexpensive Ni-electrocatalytic protocol. The reaction exhibits a broad scope, uses stock solution of simple SO2 as sulfur source, and can be scaled up in batch and recycle flow settings. The limitations of this reaction are clearly shown and put into context by benchmarking with state-of-the-art Pd-based methods. ...[more]

PMID: 35819400

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