Interference and co-existence of staphylococci and Cutibacterium acnes within the healthy human skin microbiome.

ABSTRACT: Human skin is populated by trillions of microbes collectively called the skin microbiome. Staphylococcus epidermidis and Cutibacterium acnes are among the most abundant members of this ecosystem, with described roles in skin health and disease. However, knowledge regarding the health beneficial effects of these ubiquitous skin residents is still limited. Here, we profiled the staphylococcal and C. acnes landscape across four different skin sites of 30 individuals (120 skin samples) using amplicon-based next-generation sequencing. Relative abundance profiles obtained indicated the existence of phylotype-specific co-existence and exclusion scenarios. Co-culture experiments with 557 staphylococcal strains identified 30 strains exhibiting anti-C. acnes activities. Notably, staphylococcal strai

SUBMITTER: Ahle CM 

PROVIDER: S-EPMC9452508 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature