Dataset Information

A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.

ABSTRACT: An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. To uncover the potential signaling pathway involved in capsaicin-induced relapse and the effects of capsaicin on neutrophil activation, we performed proteomic analyses of intestinal tissues from chronic colitis mice following capsaicin administration and transcriptomic analyses of dHL-60 cells after capsaicin stimulation. Collectively, these multiomic analyses identified proteins and genes that may be involved in disease flares, thereby providing new insights for future research.

SUBMITTER: Chen K

PROVIDER: S-EPMC9452536 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.

Chen Kexin K Shen Silan S Chen Yiding Y Jiang Mingshan M Hu Kehan K Zou Yuheng Y Li Lili L Zeng Zhen Z Ma Chunxiang C Dang Yuan Y Zhang Hu H

Scientific data 20220907 1

An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. To uncover the potential signaling pathway involved in capsaicin-induced relapse and the effects of capsaicin on neutrophil activation, we performed proteomic ...[more]

PMID: 36071055

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Dataset Information

A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.

Publications

A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.

Similar Datasets

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