Untargeted ultra-high-resolution mass spectrometry metabolomic profiling of blood serum in bladder cancer.

ABSTRACT: Bladder cancer (BC) is a common urological cancer of high mortality and recurrence rates. Currently, cystoscopy is performed as standard examination for the diagnosis and subsequent monitoring for recurrence of the patients. Frequent expensive and invasive procedures may deterrent patients from regular follow-up screening, therefore it is important to look for new non-invasive methods to aid in the detection of recurrent and/or primary BC. In this study, ultra-high-performance liquid chromatography coupled with ultra-high-resolution mass spectrometry was employed for non-targeted metabolomic profiling of 200 human serum samples to identify biochemical signatures that differentiate BC from non-cancer controls (NCs). Univariate and multivariate statistical analyses with external validation r

SUBMITTER: Niziol J 

PROVIDER: S-EPMC9452537 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature