Unknown

Dataset Information

0

Determination of the extent of dissection in early gastric cancer based on lymph node station power index.


ABSTRACT:

Background

The relative prognostic value of each lymph node (LN) station remains undefined in the treatment of gastric cancer. This study aimed to develop a new method to evaluate LN station ranking and define the optimal extent of lymphadenectomy for early gastric cancer.

Methods

Clinical and histopathological information from patients who underwent curative gastrectomy with lymphadenectomy between 1989 and 2018 was reviewed. The LN station power index (LNPI) of each station was estimated using a LN retrieval frequency and the 5-year overall survival of patients with absence of LN at each station. External validation was conducted to evaluate the relevance of the LNPI.

Results

A training set was developed from examination of 7009 patient records. For most nodal stations, the absence of LN was significantly associated with a poor prognosis. For the perigastric stations, the prognostic value assessed using the LNPI was in the following order: LN 4 (LNPI = 19.68), LN 3 (LNPI = 17.58), LN 6 (LNPI = 15.16), LN 1 (LNPI = 6.71), LN 2 (LNPI = 4.64) and LN 5 (LNPI = 2.86). The value rank of the extra-gastric stations was in the following order: LN 8a (LNPI = 12.93), LN 7 (LNPI = 10.51) and LN 9 (LNPI = 9.70), but the index of LN 12a (LNPI = 4.79) was higher than that of LN 11 (LNPI = 4.78). These trends in the LNPI were similar in the validation patient cohort.

Conclusions

The LNPI is a simple tool to rank the priority of each LN station dissection. The optimal extent of D1 + lymphadenectomy using LNPI was determined to be D1 with LNs 7, 8a and 9.

SUBMITTER: Jeon CH 

PROVIDER: S-EPMC9452541 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Determination of the extent of dissection in early gastric cancer based on lymph node station power index.

Jeon Chul-Hyo CH   Park Ki Bum KB   Kim Sojung S   Seo Ho Seok HS   Kim In-Ho IH   Song Kyo Young KY   Lee Han Hong HH  

BJS open 20220901 5


<h4>Background</h4>The relative prognostic value of each lymph node (LN) station remains undefined in the treatment of gastric cancer. This study aimed to develop a new method to evaluate LN station ranking and define the optimal extent of lymphadenectomy for early gastric cancer.<h4>Methods</h4>Clinical and histopathological information from patients who underwent curative gastrectomy with lymphadenectomy between 1989 and 2018 was reviewed. The LN station power index (LNPI) of each station was  ...[more]

Similar Datasets

| S-EPMC10797846 | biostudies-literature
| S-EPMC8181876 | biostudies-literature
| S-EPMC6589420 | biostudies-literature
| S-EPMC10204219 | biostudies-literature
| S-EPMC10078463 | biostudies-literature
| S-EPMC4814744 | biostudies-literature
| S-EPMC7275807 | biostudies-literature
| S-EPMC10505185 | biostudies-literature
| S-EPMC9651963 | biostudies-literature
| S-EPMC5542950 | biostudies-other