Circuit analysis reveals a neural pathway for light avoidance in Drosophila larvae.

ABSTRACT: Understanding how neural circuits underlie behaviour is challenging even in the connectome era because it requires a combination of anatomical and functional analyses. This is exemplified in the circuit underlying the light avoidance behaviour displayed by Drosophila melanogaster larvae. While this behaviour is robust and the nervous system relatively simple, the circuit is only partially delineated with some contradictions among studies. Here, we devise trans-Tango MkII, an offshoot of the transsynaptic circuit tracing tool trans-Tango, and implement it in anatomical tracing together with functional analysis. We use neuronal inhibition to test necessity of particular neuronal types in light avoidance and selective neuronal activation to examine sufficiency in rescuing light avoidance defi

SUBMITTER: Sorkac A 

PROVIDER: S-EPMC9452580 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature