[¹⁸F]FE-PE2I PET is a feasible alternative to [¹²³I]FP-CIT SPECT for dopamine transporter imaging in clinically uncertain parkinsonism.

ABSTRACT:

Background

Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson's disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present study was to evaluate the diagnostic performance of the recently developed tracer for DAT imaging [¹⁸F]FE-PE2I PET/CT to the reference standard [¹²³I]FP-CIT SPECT.

Methods

Ninety-eight unselected patients referred for DAT imaging were included prospectively and consecutively and evaluated with [¹⁸F]FE-PE2I PET/CT and [¹²³I]FP-CIT SPECT on two separate days. PET and SPECT scans were categorized independently by two blinded expert readers as either normal, vascular changes, or mixed. Semiquantitative values were obtaine

SUBMITTER: Marner L 

PROVIDER: S-EPMC9452620 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature