Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis.

ABSTRACT:

Objective

Schizophrenia (SCH) is primarily diagnosed based on specific clinical symptoms, with the lack of any objective SCH-related biomarkers often resulting in patient misdiagnosis and the underdiagnosis of this condition. This study was developed to assess the utility of amplitude of low-frequency fluctuation (ALFF) values analyzed via support vector machine (SVM) methods as a means of diagnosing SCH.

Methods

In total, 131 SCH patients and 128 age- and gender-matched healthy control (HC) individuals underwent resting-state functional magnetic resonance imaging (rs-fMRI), with the resultant data then being analyzed using ALFF values and SVM methods.

Results

Relative to HC individuals, patients with SCH exhibited ALFF reductions in the left angular gyrus (AG)

SUBMITTER: Gao Y 

PROVIDER: S-EPMC9452648 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature