Variability of body mass index and risks of prostate, lung, colon, and ovarian cancers.

ABSTRACT:

Objective

We investigated the association between cancer incidence and body mass index (BMI) variability calculated from the recall of weight at decades of age by participants in the USA Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

Methods

A total of 89,822 individuals' BMI were recorded as recalled the participant's aged 30, 40, 50, 60, 70 years, and baseline. BMI variability was assessed using four indices: SD, coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV). The multivariate Cox regression analysis was performed to calculate hazard ratios (HRs) of these measures for incident cancers and corresponding 95% CIs.

Results

During the median follow-up of 11.8 years, there were newly diag

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9452651 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature