Hierarchical regulation of Burkholderia glumae type III secretion system by GluR response regulator and Lon protease.

ABSTRACT: Expression of type III secretion system (T3SS) genes, which are important for the virulence of phytopathogenic bacteria, is induced in the plant apoplastic environment or artificially amended growth conditions. Wild-type Burkholderia glumae BGR1, which causes rice panicle blight, induced a hypersensitive response (HR) in tobacco plants, whereas the T3SS genes were not significantly expressed in the commonly used hrp induction medium. T3SS gene expression in B. glumae was dependent on HrpB, a well known T3SS gene transcriptional regulator. Here, we report a stepwise mechanism of T3SS gene regulation by the GluR response regulator and Lon protease in addition to HrpB-mediated control of T3SS genes in B. glumae. The gluR mutant showed no HR in tobacco plants and exhibited attenuated virulence

SUBMITTER: Marunga J 

PROVIDER: S-EPMC9452761 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature