Cortical neuroanatomical changes related to specific language impairments in primary progressive aphasia.

ABSTRACT:

Objective

Language function test-specific neural substrates in Korean patients with primary progressive aphasia (PPA) might differ from those in other causes of dementia and English-speaking PPA patients. We investigated the correlation between language performance tests and cortical thickness to determine neural substrates in Korean patients with PPA.

Materials and methods

Ninety-six patients with PPA were recruited from the memory clinic. To acquire neural substrates, we performed linear regression using the scores of each language test as a predictor, cortical thickness as an outcome and age, sex, years of education, and intracranial volume as confounders.

Results

Poor performance in each language function test was associated with lower cortical thickness in specif

SUBMITTER: Kang SH 

PROVIDER: S-EPMC9452784 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature