Effect of atorvastatin on skeletal muscles of patients with knee osteoarthritis: Post-hoc analysis of a randomised controlled trial.

ABSTRACT:

Objective

Populations with knee osteoarthritis (KOA) are at increased risk of cardiovascular disease, due to higher prevalence of risk factors including dyslipidaemia, where statins are commonly prescribed. However, the effect of statins on muscles and symptoms in this population is unknown. Thus, this study examined the effect of atorvastatin on muscle properties in patients with symptomatic KOA.

Design

Post-hoc analysis of a 2-year multicentre randomised, double-blind, placebo-controlled trial.

Setting

Australian community.

Participants

Participants aged 40-70 years (mean age 55.7 years, 55.6% female) with KOA who met the American College of Rheumatology clinical criteria received atorvastatin 40 mg daily (n = 151) or placebo (n = 153).

SUBMITTER: Lim YZ 

PROVIDER: S-EPMC9452814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature