Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of shiliao decoction in the treatment of cancer-associated malnutrition.

ABSTRACT:

Purpose

Shiliao Decoction (SLD) was developed for treatment and prevention of cancer-associated malnutrition (CAM) in China. In this study, we aim to discover SLD's active compounds and demonstrate the mechanisms of SLD that combat CAM through network pharmacology and molecular docking techniques.

Methods

All components of SLD were retrieved from the pharmacology database of Traditional Chinese Medicine Systems Pharmacology (TCMSP). The GeneCards database and the Online Mendelian Inheritance in Man database (OMIM) were used to identify gene encoding target compounds, and Cytoscape was used to construct the drug compound-target network. The network of target protein-protein interactions (PPI) was constructed using the STRING database, while gene ontology (GO) functional terms

SUBMITTER: Long S 

PROVIDER: S-EPMC9452828 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature