Network analysis of hepatocellular carcinoma liquid biopsies augmented by single-cell sequencing data.

ABSTRACT: Liquid biopsy, the analysis of body fluids, represents a promising approach for disease diagnosis and prognosis with minimal intervention. Sequencing cell-free RNA derived from liquid biopsies has been very promising for the diagnosis of several diseases. Cancer research, in particular, has emerged as a prominent candidate since early diagnosis has been shown to be a critical determinant of disease prognosis. Although high-throughput analysis of liquid biopsies has uncovered many differentially expressed genes in the context of cancer, the functional connection between these genes is not investigated in depth. An important approach to remedy this issue is the construction of gene networks which describes the correlation patterns between different genes, thereby allowing to infer their func

SUBMITTER: Safrastyan A 

PROVIDER: S-EPMC9452847 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature