CD4⁺CD8⁺ T follicular helper cells regulate humoral immunity in chronic inflammatory lesions.

ABSTRACT: T follicular helper (Tfh) cells drive humoral immunity by facilitating B cell responses at the initial and recall phases. Recent studies have indicated the possible involvement of Tfh cells in the process of chronic inflammation. However, the functional role of Tfh cells in persistent immune settings remains unclear. Here, we report that CD4⁺CD8⁺ (double-positive, DP; CD3⁺CD4⁺CD8⁺CXCR5^hiPD-1^hi) Tfh cells, a subset of germinal-center-type Tfh cells, were abundantly present in the fibroinflammatory lesions of patients with immunoglobulin G4-related disease (IgG4-RD). Transcriptome analyses showed that these DP-Tfh cells in the lesions of IgG4-RD preferentially expressed signature genes characteristic of cytotoxic CD

SUBMITTER: Murayama K 

PROVIDER: S-EPMC9452889 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature