LNG-IUS vs. medical treatments for women with heavy menstrual bleeding: A systematic review and meta-analysis.

ABSTRACT:

Introduction

To compare efficacy and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) with medical treatments for women with heavy menstrual bleeding.

Materials and methods

We searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), and Wanfang databases for relevant randomized controlled trials (RCTs) in November 2021. All meta-analyses were performed using the random-effects model. PROSPERO registration number: CRD42021295379.

Results

A total of trials (with 14 references) reporting on 1,677 women were included in this systematic review. The majority of the included RCTs were rated with low-to-unclear risk of bias in selection, detection, attrition, reporting, and other bias. All

SUBMITTER: Chen S 

PROVIDER: S-EPMC9452891 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature