Hospital outbreak of carbapenem-resistant Enterobacterales associated with a <i>bla</i>_OXA-48 plasmid carried mostly by <i>Escherichia coli</i> ST399.

ABSTRACT: A hospital outbreak of carbapenem-resistant Enterobacterales was detected by routine surveillance. Whole genome sequencing and subsequent analysis revealed a conserved promiscuous bla_OXA-48 carrying plasmid as the defining factor within this outbreak. Four different species of Enterobacterales were involved in the outbreak. Escherichia coli ST399 accounted for 35 of all the 55 isolates. Comparative genomics analysis using publicly available E. coli ST399 genomes showed that the outbreak E. coli ST399 isolates formed a unique clade. We developed a mathematical model of pOXA-48-like plasmid transmission between host lineages and used it to estimate its conjugation rate, giving a lower bound of 0.23 conjugation events per lineage per year. Our analysis s

SUBMITTER: Ledda A 

PROVIDER: S-EPMC9453065 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature