Pathogenomes and variations in Shiga toxin production among geographically distinct clones of Escherichia coli O113:H21.

ABSTRACT: Infections with globally disseminated Shiga toxin-producing Escherichia coli (STEC) of the O113:H21 serotype can progress to severe clinical complications, such as hemolytic uremic syndrome (HUS). Two phylogeographically distinct clonal complexes have been established by multi locus sequence typing (MLST). Infections with ST-820 isolates circulating exclusively in Australia have caused severe human disease, such as HUS. Conversely, ST-223 isolates prevalent in the US and outside Australia seem to rarely cause severe human disease but are frequent contaminants. Following a genomic epidemiology approach, we wanted to gain insights into the underlying cause for this disparity. We examined the plasticity in the genome make-up and Shiga toxin production in a collection of 20 ST-820 and S

SUBMITTER: Allue-Guardia A 

PROVIDER: S-EPMC9453080 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature