Molecular characterization, clinical relevance and immune feature of m7G regulator genes across 33 cancer types.

ABSTRACT: Over 170 RNA modifications have been identified after transcriptions, involving in regulation of RNA splicing, processing, translation and decay. Growing evidence has unmasked the crucial role of N⁶-methyladenosine (m6A) in cancer development and progression, while, as a relative newly found RNA modification, N⁷-methylguanosine (m7G) is also certified to participate in tumorigenesis via different catalytic machinery from that of m6A. However, system analysis on m7G RNA modification-related regulator genes is lack. In this study, we first investigated the genetic alteration of m7G related regulator genes in 33 cancers, and found mRNA expression levels of most regulator genes were positively correlated with copy number variation (CNV) and negatively correlated wi

SUBMITTER: Li Z 

PROVIDER: S-EPMC9453236 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature