Fronto-parietal Cortical Circuits Encode Accumulated Evidence with a Diversity of Timescales.

ABSTRACT: Decision-making in dynamic environments often involves accumulation of evidence, in which new information is used to update beliefs and select future actions. Using in vivo cellular resolution imaging in voluntarily head-restrained rats, we examined the responses of neurons in frontal and parietal cortices during a pulse-based accumulation of evidence task. Neurons exhibited activity that predicted the animal's upcoming choice, previous choice, and graded responses that reflected the strength of the accumulated evidence. The pulsatile nature of the stimuli enabled characterization of the responses of neurons to a single quantum (pulse) of evidence. Across the population, individual neurons displayed extensive heterogeneity in the dynamics of responses to pulses. The diversity of responses

SUBMITTER: Scott BB 

PROVIDER: S-EPMC9453285 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature