Bihormonal Artificial Pancreas With Closed-Loop Glucose Control vs Current Diabetes Care After Total Pancreatectomy: A Randomized Clinical Trial.

ABSTRACT:

Importance

Glucose control in patients after total pancreatectomy is problematic because of the complete absence of α- and β-cells, leading to impaired quality of life. A novel, bihormonal artificial pancreas (BIHAP), using both insulin and glucagon, may improve glucose control, but studies in this setting are lacking.

Objective

To assess the efficacy and safety of the BIHAP in patients after total pancreatectomy.

Design, setting, and participants

This randomized crossover clinical trial compared the fully closed-loop BIHAP with current diabetes care (ie, insulin pump or pen therapy) in 12 adult outpatients after total pancreatectomy. Patients were recruited between August 21 and November 16, 2020. This first-in-patient study began with a feasibility phase in 2 patien

SUBMITTER: van Veldhuisen CL 

PROVIDER: S-EPMC9453632 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature