Use of oral anti-diabetic drugs and risk of hospital and intensive care unit admissions for infections.

ABSTRACT:

Background

Sepsis is one of the leading causes of hospital mortality, and diabetes is a risk factor for the development of infections. Although strong evidence has shown an association between metformin and reduced risk of infections, the risk of developing infections with newer classes of oral anti-diabetic drugs (OADs) has been less certain. Our study aims to examine the association between outpatient OAD use and hospital admissions for infections.

Methods

The study cohort included 1.39 million adults with diabetes utilizing the Veterans Health Affairs Corporate Data Warehouse. Multivariate logistic regression was used to estimate the effect of each drug class on hospital admission for infection while adjusting for covariates.

Results

After adjusting for covariates,

SUBMITTER: Rim J 

PROVIDER: S-EPMC9453653 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature