Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer.

ABSTRACT:

Objective

Innate and acquired resistance is the principle factor limiting the efficacy of tyrosine kinase inhibitors in lung cancer. We have observed a dramatic upregulation of the cell surface co-receptor neuropilin-2b in lung cancers clinically treated with tyrosine kinase inhibitors correlating with acquired resistance. We hypothesize that neuropilin-2b plays a functional role in acquired tyrosine kinase inhibitor resistance.

Methods

Non-small cell lung cancer proliferation and survival were determined during chronic tyrosine kinase inhibitor exposure in the presence or absence of neuropilin-2b knock-down. Interactions of neuropilin-2a and neuropilin-2b isoforms with PTEN and GSK3β were assessed by immunoprecipitation. Neuropilin-2a and neuropilin-2b mutants deleted for t

SUBMITTER: Dimou A 

PROVIDER: S-EPMC9453694 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature