Evaluation of in Vitro Activity of Ceftazidime/Avibactam and Ceftolozane/Tazobactam against ESBL-producing Enterobacterales Isolated from Intensive Care Units from Qatar.

ABSTRACT:

Objectives

Extended-spectrum -lactamases (ESBLs) mechanism of resistance in Enterobacterales leads to poor clinical outcomes. Ceftazidime/avibactam and ceftolozane/tazobactam are two broad-spectrum antimicrobial combinations that are effective against multidrug-resistant organisms with regional variations. This study aims to evaluate the antimicrobial susceptibility test (AST) for both combinations against ESBL-producing Enterobacterales isolated from intensive care units (ICUs) in tertiary hospitals from November 2012 to October 2013 in Qatar.

Methods

A total of 629 Enterobacterales isolates from ICUs were screened for ESBL production using BD-Phoenix^TM confirmed by double-disk potentiation, while ESBL-genes were detected by polymerase chain reaction. The ASTs fo

SUBMITTER: Ahmed MAS 

PROVIDER: S-EPMC9453757 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature