Temporal changes of the respiratory microbiota as cats transition from health to experimental acute and chronic allergic asthma.

ABSTRACT: In humans, deviation from a core airway microbiota may predispose to development, exacerbation, or progression of asthma. We proposed to describe microbiota changes using 16 rRNA sequencing in samples from the upper and lower airways, and rectal swabs of 8 cats after experimental induction of asthma using Bermuda grass allergen, in acute (6 weeks) and chronic (36 weeks) stages. We hypothesized that asthma induction would decrease richness and diversity and alter microbiota composition and structure in the lower airways, without significantly impacting other sites. After asthma induction, richness decreased in rectal (p = 0.014) and lower airway (p = 0.016) samples. B diversity was significantly different between health and chronic asthma in all sites, and between all time poi

SUBMITTER: Vientos-Plotts AI 

PROVIDER: S-EPMC9453837 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature