Circulating immune cell landscape in patients who had mild ischaemic stroke.

ABSTRACT:

Introduction

Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed, are excluded from treatment and in some cases clinically worsen. Circulating immune cells are potential biomarkers that can assist with diagnosis in ischaemic stroke. Understanding the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated relationship. In this study, we investigated peripheral blood mononuclear cells (PBMCs) transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased way.

Methods

Transcriptomes of PBMCsfrom 10 patients who had an acute isch

SUBMITTER: Cho YE 

PROVIDER: S-EPMC9453838 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature