Theoretical Investigation of the Biogenetic Pathway for Formation of Antibacterial Indole Alkaloids from Voacanga africana.
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ABSTRACT:
SUBMITTER: Soysal EN
PROVIDER: S-EPMC9453972 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Theoretical Investigation of the Biogenetic Pathway for Formation of Antibacterial Indole Alkaloids from <i>Voacanga africana</i>.
Soysal Esra N EN Fındık Volkan V Dedeoglu Burcu B Aviyente Viktorya V Tantillo Dean J DJ
ACS omega 20220824 35
The energetic viability of the previously proposed biogenetic pathway for the formation of two unique monoterpenoid indole alkaloids, voacafricine A and B, which are present in the fruits of <i>Voacanga africana</i>, was investigated using density functional theory computations. The results of these calculations indicate that not only is the previously suggested pathway not energetically viable but also that an alternative biosynthetic precursor is likely. ...[more]
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