Histone H4K20 Trimethylation Is Decreased in Murine Models of Heart Disease.

ABSTRACT: Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart failure, there are global epigenetic alterations to chromatin that occur concomitantly with morphological changes in the heart in response to acute and chronic stress. These epigenetic alterations include the reversible methylation of lysine residues on histone proteins. Lysine methylations on histones H3K4 and H3K9 were among the first methylated lysine residues identified and have been linked to gene activation and silencing, respectively. However, much less is known regarding other methylated histone residues, including histone H4K20. Trime

SUBMITTER: Hickenlooper SM 

PROVIDER: S-EPMC9453978 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature