Single-centre case–control study investigating the association between acanthosis nigricans, insulin resistance and type 2 diabetes in a young, overweight, UK population

ABSTRACT:

Objective

To determine the extent to which the presence of acanthosis nigricans confers additional risk for insulin resistance, in addition to obesity alone (body mass index, BMI) within a young, overweight, UK population.

Research design and methods

Retrospective data were collected to compare the degree of insulin resistance within a sample of 94 young people with acanthosis nigricans, and a matched cohort of 94 participants with obesity alone. Insulin resistance was assessed by fasting glucose, fasting insulin and Homeostatic Model Assessment of insulin resistance (HOMA-IR) score (a mathematical model derived to measure insulin resistance).

Results

The acanthotic and control group were well matched for age, BMI, BMI SDS and sex, although the groups were not ma

SUBMITTER: Callanan N 

PROVIDER: S-EPMC9454057 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature