Modulation of α-Synuclein Aggregation In Vitro by a DNA Aptamer.

ABSTRACT: Protein aggregation is an important problem for human health and biotechnology, with consequences in areas ranging from neurodegenerative diseases to protein production yields. Methods to modulate protein aggregation are therefore essential. One suggested method to modulate protein aggregation is the use of nucleic acid aptamers, that is, single-stranded nucleic acids that have been selected to specifically bind to a target. Previous studies in some systems have demonstrated that aptamers may inhibit protein aggregation, including for α-synuclein, a protein implicated in synucleinopathies. However, the mechanisms by which aptamers might affect or modulate aggregation have not been fully determined. In this study, we investigated the effect of an aptamer that binds α-synuclein oligomer, T-S

SUBMITTER: Tran CH 

PROVIDER: S-EPMC9454088 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature