Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila.

ABSTRACT:

Background

Drosophila melanogaster lipophorin receptors (LpRs), LpR1 and LpR2, are members of the LDLR family known to mediate lipid uptake in a range of organisms from Drosophila to humans. The vertebrate orthologs of LpRs, ApoER2 and VLDL-R, function as receptors of a glycoprotein involved in development of the central nervous system, Reelin, which is not present in flies. ApoER2 and VLDL-R are associated with the development and function of the hippocampus and cerebral cortex, important association areas in the mammalian brain, as well as with neurodevelopmental and neurodegenerative disorders linked to those regions. It is currently unknown whether LpRs play similar roles in the Drosophila brain.

Results

We report that LpR-deficient flies exhibit impaired olfactory memor

SUBMITTER: Rojo-Cortes F 

PROVIDER: S-EPMC9454125 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature