METTL1 promotes neuroblastoma development through m⁷G tRNA modification and selective oncogenic gene translation.

ABSTRACT:

Background

Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approaches, the 5-year event-free survival (EFS) for patients with advanced NBL remains below 30%, emphasizing urgent necessary for novel therapeutic strategies. Studies have shown that epigenetic disorders play an essential role in the pathogenesis of NBL. However, the function and mechanism of N7-methylguanosine (m⁷G) methyltransferase in NBL remains unknown.

Methods

The expression levels of m⁷G tRNA methyltransferase Methyltransferase-like 1 (METTL1) were analyzed by querying the Gene Expression Omnibus (GEO) database and further confirmed by

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9454133 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature