The changes in peripheral blood Th17 and Treg ratios in Hashimoto's thyroiditis are accompanied by differential PD-1/PD-L1 expression.

ABSTRACT:

Objective

The aim of this study was to analyze the percentages of T helper 17 cells (Th17s) and T regulatory cells (Tregs) in autoimmune Hashimoto's thyroiditis (HT), and the expression of the checkpoint molecules programmed death receptor 1/programmed death ligand 1 (PD-1/PD-L1) on these cells.

Methods

This is a case-control study involving 53 initially diagnosed HT patients (HT group) and 21 normal controls (NC group). The peripheral blood mononuclear cells from the individuals of the two groups were isolated and restimulated ex vivo; the percentage of Th17s, Tregs, PD-1⁺ Th17s, PD-L1⁺ Th17s, PD-1⁺ Tregs, and PD-L1⁺ Tregs was assessed by flow cytometric analysis.

Results

(1) The percentage of Th17s in the peripheral

SUBMITTER: Fang J 

PROVIDER: S-EPMC9454193 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature