External validation of models for predicting risk of colorectal cancer using the China Kadoorie Biobank.

ABSTRACT: In China, colorectal cancer (CRC) incidence and mortality have been steadily increasing over the last decades. Risk models to predict incident CRC have been developed in various populations, but they have not been systematically externally validated in a Chinese population.  This study aimed to assess the performance of risk scores in predicting CRC using the China Kadoorie Biobank (CKB), one of the largest and geographically diverse prospective cohort studies in China. Nine models were externally validated in 512,415 participants in CKB and included 2976 cases of CRC. Model discrimination was assessed, overall and by sex, age, site, and geographic location, using the area under the receiver operating characteristic curve (AUC). Model discrimination of these nine models was compared to a m

SUBMITTER: Abhari RE 

PROVIDER: S-EPMC9454206 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature