Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice.

ABSTRACT: The portfolio of SARS-CoV-2 small molecule drugs is currently limited to a handful that are either approved (remdesivir), emergency approved (dexamethasone, baricitinib, paxlovid, and molnupiravir), or in advanced clinical trials. Vandetanib is a kinase inhibitor which targets the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), as well as the RET-tyrosine kinase. In the current study, it was tested in different cell lines and showed promising results on inhibition versus the toxic effect on A549-hACE2 cells (IC₅₀ 0.79 μM) while also showing a reduction of >3 log TCID₅₀/mL for HCoV-229E. The in vivo efficacy of vandetanib was assessed in a mouse model of SARS-CoV-2 infection and statistically significantly reduced the l

SUBMITTER: Puhl AC 

PROVIDER: S-EPMC9454268 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature