Genomic Landscape Alterations in Primary Tumor and Matched Lymph Node Metastasis in Hormone-Naive Prostate Cancer Patients.

ABSTRACT:

Background

Prostate cancer (PCa) is a disease with a wide range of clinical manifestations. Up to the present date, the genetic understanding of patients with favorable or unfavorable prognosis is gaining interest for giving the appropriate tailored treatment. We aimed to investigate genetic changes associated with lymph node metastasis in a cohort of hormone-naïve Pca patients.

Methods

We retrospectively analyzed data from 470 patients who underwent surgery for PCa between 2010 and 2020 at the Department of Urology, University of Catania. Inclusion criteria were patients with lymph node metastasis and patients with PCa with extra capsular extension (pT3) and negative lymph node metastasis. The final cohort consisted of 17 different patients (11 PCa with lymph node metastasi

SUBMITTER: Russo GI 

PROVIDER: S-EPMC9454441 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature